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Resident Evil: Extinction is a 2007 science fiction action horror film. It is the third installment in the series of film adaptations based on the Capcom survival horror series Resident Evil. The film follows the amnesiac heroine Alice, along with a group of survivors from Raccoon City, as they attempt to travel across the Mojave desert wilderness to Alaska and escape a zombie apocalypse.[1] The film was directed by Russell Mulcahy and produced by Paul W. S. Anderson.

The film was released in the United States on September 21, 2007 and was commercially successful, grossing $147,717,833 worldwide,[2] however, it received many negative reviews from critics. The film was released on DVD and Blu-ray in North America on January 1, 2008.\
Following the events of the Raccoon City incident in Apocalypse, the T-Virus escaped containment despite the nuclear destruction of the city. The virus then spread from Raccoon City to San Francisco, and the Umbrella Corporation was unable to contain it. The virus quickly spread across the world, drying up the lakes, rivers, and continents while infecting the majority of the human population and spreading to other species. Five years later, The Umbrella Corporation appears to be the only organized society of humans left, its remnants forced to live underground in Hive-like constructs dispersed around the world.

Alice (Milla Jovovich), is now alone in the desert wastelands of the remains of the United States. She has superhuman strength and psionic abilities gained from her brief imprisonment by Umbrella. Umbrella considers re-capturing Alice a top priority because of her bloods ability to bond with the T-Virus. Dr. Sam Isaacs (Iain Glen) believes that he can use blood from the original Alice to develop a permanent cure, as well as tame the undead. Umbrella chairman Albert Wesker (Jason OMara) orders Isaacs to create a cure without Alice, using clones created from her blood. Wesker refuses to authorize manpower to recover Alice until they are 100% sure where she is, due to the high risk involved in missions on the surface. The Alice clones endure countless tests within the re-created Spencer Mansion, The Hive, and Raccoon City Hospital locations.

Meanwhile, Claire Redfields (Ali Larter) convoy, which includes Alices fellow Raccoon survivors Carlos Olivera (Oded Fehr) and L.J. (Mike Epps), along with new survivors K-Mart (Spencer Locke), Mikey (Chris Egan), Chase (Linden Ashby) and Nurse Betty (Ashanti), are attempting to survive. While searching a small motel for supplies, L.J. is bitten, but he does not inform the others. The next morning a flock of infected crows attack the convoy. The battle is going badly until Alice appears using her newly-developing telekinetic powers to incinerate the flock by covering the sky in flames from a nearby fire.

Dr. Isaacs attempts to domesticate the undead have led to a new breed of zombie but is uncovered by Captain Slater (Matthew Marsden), Weskers subordinate. Slater reprimands Isaacs, but grudgingly admits that these Super Zombies may be useful in capturing Project Alice.

Alice is introduced to Claire, and gives her a diary she found in a deserted gas station. The diary tells of radio transmissions claiming a infection free population living in Alaska. Both Alice and Carlos convince Claire the convoy should head to Alaska. The other survivors agree to head for Las Vegas to obtain supplies before the trek to Alaska.

The Umbrella corporation, with the help of the White Queen, is able to triangulate Alices location based on the use of her psionic powers. Dr. Isaacs defies Weskers direct orders and has a crate of his newly created zombies transported to ambush the convoy. In the carnage, Carlos becomes infected by L.J before being shot, and most of the convoy is killed. Umbrella attempts to shut Alice down, but she manages to destroy the CPU on Umbrellas tracking satellite. She locates Isaacs at the scene, just as he slips away in a helicopter, he becomes infected by a zombie. Intending to capture the helicopter for the survivors escape to Alaska, Alice and the others follow the helicopters flight path, thus learning of Umbrellas underground location.

The convoy survivors find the location of Umbrellas Las Vegas facility surrounded by hundreds of zombies. Carlos infection has gone beyond a cure, and he decides to sacrifice himself for the convoy. Carlos plows through the facility before setting off a dynamite charge, giving Alice and Claire enough time to load the survivors onto the helicopter, which is piloted by Claire. Alice decides to stay behind.

Dr. Isaacs, having been arrested by Umbrella after his return from the failed mission, has been locked in his lab. Ordered to "liquidate" Isaacs, Slater finds him sprawled at his lab desk, injecting himself with massive doses of Anti-Virus. Isaacs explains that the strain of T-Virus carried by the Super Zombies is more potent, having been mixed with Alices blood, and therefore he needs much more Anti-Virus. However, the Anti-Virus overdose triggers a massive mutation of Isaacs into a Tyrant. Isaacs goes on a rampage, killing all the employees in the facility, but eventually the White Queen manages to confine Isaacs in the lower levels of the lab.

Entering the facility, Alice meets a holographic representation of the White Queen. The recent homicidal tendencies of her sister fresh in Alices mind, she nevertheless strikes an uneasy truce with her. The White Queen informs Alice that her blood is the cure to the T-Virus, and can end the madness. The Queen then informs Alice of her current problem with Dr. Isaacs, and Alice agrees to deal with him.

On her way to the labs lower levels, Alice comes across a clone of herself still in a vegetative state. As she is examining the clone, Isaacs attacks her, but she manages to fight him off. The clone awakens, but the shock of the sudden awakening apparently kills her. Alice goes after Isaacs and finds herself in a replica of the Spencer Mansion, where a battle between Isaacs and Alice ensues, with both displaying use of telekinesis and cunning skill and strategy. When the fight spills into a replica of the laser corridor from The Hive, Alice grimly informs Isaacs that they are both to die there when the lasers activate. The laser grid slices Isaacs into pieces in the same fashion as the characters "Donald", "One", and Shade", but just as Alice is about to meet the same fate, the lasers are deactivated by the clone of Alice in the nick of time.

Meanwhile, in Tokyo, Japan, Wesker informs the rest of the Umbrella board that the North American branch has been lost, and he will now control further scientific experimentation from Japan. Using holographic technology, Alice makes an appearance at the board meeting, declaring that she and her friends are coming for them now. Standing beside the clone of herself, Alice looks onto the rows of pods containing other clones, their numbers in the hundreds. As many clones begin to awaken, the film ends.